Backup_of_final Issue 1.cdr
نویسندگان
چکیده
dependent variables that were selected for study were, particle size (Y ) and % drug entrapment (Y ). The derived 1 2 polynomial equations were verified by check point formulation. The application of factorial design gave a statistically systematic approach for the formulation and optimization of nanoparticles with desired particle size, % drug release and high entrapment efficiency. Drug:polymer ratio and concentration of stabilizer were found to influence the particle size ® and entrapment efficiency of acyclovir loaded Eudragit RLPO nanoparticles. The release was found to follow nonFickian diffusion mechanism with first order drug release for all batches.These preliminary results indicate that acyclovir ® loaded Eudragit RLPO nanoparticles could be effective in sustaining drug release for a prolonged period. ® 2
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